PGC1α Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis
نویسندگان
چکیده
منابع مشابه
PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.
Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of the mitochondria and biosynthetic pathways as well. PPARγ coactivator 1α (PGC1α) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis. Initial studies suggested that PGC1α expression is reduced in tumors compared with adjacent normal tissue. Par...
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Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of themitochondria and biosynthetic pathways as well. PPARg coactivator 1a (PGC1a) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis. Initial studies suggested that PGC1a expression is reduced in tumors compared with adjacent normal tissue. Para...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2011
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-11-1011